Research pick: Natural nanotech anticancer drug - "Preparation of liposomes containing benzophenanthridine alkaloid sanguinarine and evaluation of its cytotoxic activity"

Sanguinarine is a natural product, a chemical made by certain plants including the bloodroot plant (Sanguinaria canadensis), the Mexican prickly poppy (Argemone mexicana), Chelidonium majus, and Macleaya cordata. It is a slightly toxic polycyclic ammonium ion, an alkaloid, and has been demonstrated to have antitumour and antiviral properties. It also blocks the formation of blood vessels, it is antiangiogenic, and so has even greater potential as an anticancer agent.



Now, a team from Russia has investigated the potential of this compound to be delivered to diseased target sites in the body using nanoscopic carriers known as liposomes. The team suggests that the liposomes can more efficiently deliver the putative drug compound to cancer cells than it simply being delivered by conventional chemotherapy methods (as a drug solution given either by mouth or intravenously).

Their tests revealed that the liposome preparations gave a prolonged release of the drug rather than it being processed quickly by the liver and excreted by the kidneys as happens with conventional drugs. Indeed, the drug-bearing liposomes showed a dose-dependent response in terms of cytotoxicity in the laboratory against B16 cells (experimental mouse melanoma cells).

“Liposomal sanguinarine may have advantages for in vivo anticancer therapy, due to its lower toxicity and ‘passive targeting’ as a result of enhanced permeability of tumour vessels,” the team reports in the International Journal of Nanotechnology.

Feldman, N.B., Kuryakov, V.N., Sedyakina, N.E., Gromovykh, T.I. and Lutsenko, S.V. (2018) ‘Preparation of liposomes containing benzophenanthridine alkaloid sanguinarine and evaluation of its cytotoxic activity’, Int. J. Nanotechnol., Vol. 15, Nos. 4/5, pp.280-287.