26 May 2023

Research pick: Patient, heal thyself! With the help of bioinformatics - "Health 2050: faster cure via bioinformatics and quantified self; a design analysis"

Healthcare costs continue to rise due to the burden of major diseases like cardiovascular, oncological, neurological, and metabolic conditions. These conditions account for about three-quarters of costs and resources. However, modern medicine does not generally seek to prevent or cure such problems, rather it addresses symptoms when they arise and then, if complete remission is not achieved, largely manages the conditions as chronic illnesses.

The next advances in medicine could help us avoid certain health problems altogether and to treat acutely those that do arise so that they are reversed or the person goes into complete remission. There are, according to optimistic research in the International Journal of Networking and Virtual Organisations opportunities to use the body’s natural ability to repair itself within a short timeframe with the help of bioinformatics.

Luuk P.A. Simons Department of the department of Computer Science at Delft University of Technology, in The Netherlands, recognises that healthcare and medicine has many challenges to overcome before we approach this self-healing utopia. But, the latest advances in rapid recovery research point towards using daily bioinformatics feedback and biomarkers (natural chemicals in our body that are associated with different health or disease states) in our bodies to guide treatment. Simons suggests that this approach would allow people to develop a quantified self-profile, which he refers to as an “endoself.” The endoself would offer a person crucial insights into their health and potentially give them biological opportunities for self-repair and cure.

This approach might be described as a paradigm shift. It entails moving away from our reliance on symptomatic diagnostics and the subsequent pharmaceutical and surgical interventions, towards an approach that uses bioinformatics and biomarkers to identify health problems the moment they arise and to trigger a wound-healing paradigm, perhaps with the minimal of interventions we might refer to as external fixes. Ultimately, this approach would be to the benefit of everyone in terms of individual health and costs to healthcare systems.

This healthcare shift relies on our knowing the biomarkers, of having ways to monitor them in near real-time, and to have means to stimulate the body to respond to potentially detrimental changes in the levels of those biomarkers in our bodies. Obviously, such stimulation might be pharmaceutical, but the paradigm shift is that it would be proactive in addressing a problem before obvious symptoms arise, rather than simply reacting to symptoms. There are barriers but Simons is optimistic that we can overcome these although one of the biggest obstacles, he suggests, is the shift from reimbursement-based medicine to evidence-based medicine.

We have seen with social media during the last decade or so a shift to a new paradigm in the dissemination and interpretation of news and information, one that involves individuals using tools to share and comment, rather than relying on traditional corporations to pick and choose what we read and watch. Simons’ healthcare paradigm would, similarly, empower the individual to take up the new tools of the trade to take care of themselves rather than relying wholly on the medical-industrial complex.

Simons, L.P.A. (2023) ‘Health 2050: faster cure via bioinformatics and quantified self; a design analysis’, Int. J. Networking and Virtual Organisations, Vol. 28, No. 1, pp.36–52.

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